The goal of the Impact of Non-B HIV-1 Subtype on second-line Protease Inhibitor Regimens in Africa (INSPIRE) project is to identify factors that predict virological failure among patients with Protease Inhibitor (PI) containing regimens.
The goal of the Impact of Non-B HIV-1 Subtype on second-line Protease Inhibitor Regimens in Africa (INSPIRE) project is to identify factors that predict virological failure among patients with Protease Inhibitor (PI) containing regimens. These patients however, have no resistance using the conventional drug resistance testing assay, and are infected with wide range of HIV subtypes in Cameroon, Uganda, South Africa and Nigeria. Findings from this study will provide further understanding on resistance to HIV drugs and inform National and International HIV/AIDS Treatment Guidelines.
Collaborators: Miguel E. Quiñones-Mateu, Ph.D. Professor, Webster Family Chair in Viral Pathogenesis, Associate Dean Research, Department of Microbiology & Immunology, School of Biomedical Sciences
University of Otago, New Zealand
Bob Shafer, MD Division Infectious Diseases, Department Medicine, Stanford University, US
Eric O. Freed, PhD HIV Dynamics and Replication Program, NIH/NCI