The Therapeutics for Inpatients with COVID-19 (TICO) study is a follow up on the In-patient Treatment with Anti-Coronavirus Immunoglobulin (ITAC) study, which was also implemented by the Institute of Human Virology Nigeria (IHVN).
The Therapeutics for Inpatients with COVID-19 (TICO) study is a follow up on the In-patient Treatment with Anti-Coronavirus Immunoglobulin (ITAC) study, which was also implemented by the Institute of Human Virology Nigeria (IHVN). TICO is a master protocol to evaluate the safety and efficacy of multiple drugs aimed at modifying the human immune response to SARS-CoV-2 infection, or directly improving viral control in order to limit disease progression.
TICO is a randomized, blinded, controlled study which allows multiple drugs to be tested during the course of the study. This allows for efficient testing of new drugs against placebo and standard of care (SOC) treatment within the same study. An independent Data and Safety Monitoring Board (DSMB) will regularly review interim analyses and summarize safety and efficacy results to delineate which drug(s) are beneficial for the treatment of COVID 19 symptomatic disease.
The primary aim of this study is to evaluate patients who experience sustained recovery from the time after receiving the investigational drug. This study is being implemented in Africa by the International Research Center of Excellence of the Institute of Human Virology Nigeria collaborating with the University of Abuja Teaching Hospital Gwagwalada (UATH) and the Nigerian COVID-19 Research Consortium (NCRC). TICO is funded by the US National Institute of Allergy and Infectious Diseases (NIAID) with the National PI as Dr Eriobu Nnakelu.C.