This study focused was a longitudinal prospective cohort study that employed a behavioral survey as well as clinical evaluations to measure HIV and Sexually Transmitted Infection (STI) incidences of, and determine the best practices for, engaging Men who have Sex with Men (MSM) into prevention and care services. The National Institutes of Health (NIH) study had three aims.
This study focused was a longitudinal prospective cohort study that employed a behavioral survey as well as clinical evaluations to measure HIV and Sexually Transmitted Infection (STI) incidences of, and determine the best practices for, engaging Men who have Sex with Men (MSM) into prevention and care services. The National Institutes of Health (NIH) study had three aims.
- To evaluate the network-based recruitment and quantification of the acceptability of test and treat.
- To measure the impact of the TRUST intervention on prevention outcomes, and
- To define an optimal service delivery model for MSM in Nigeria.
Findings showed that;
- In contrast to the mostly consistent microbial communities identified in the mothers, the microbiomes of HIV-exposed, uninfected and HIV-unexposed, uninfected infants showed striking differences based on the mother’s status
- At six months post-partum: α-diversity (Shannon index) in the meconium/stool of HIV Exposed Uninfected infants is significantly higher, when compared to HIV Unexposed Uninfected infants. Trend towards higher diversity in HIV Exposed Uninfected infants is maintained when adjusted for cotrimoxazole prophylaxis and breastfeeding.
- The bacterial community composition of the infants’ meconium and stool changed over time, and correlated to the mother’s HIV status. HIV Exposed Uninfected infants had more abundant populations of Bifidobacteriaceae and Enterococcaceae, whereas HIV Exposed Uninfected infants had more Ruminococcaceae, Pseudomonadaceae, and Enterobacteriaceae in their stools.