The Vaccination for Recovered In-patients with COVID-19 (VATICO) study is a phase 4 open-label trial which will be Investigating the difference in antibody level to mRNA (Moderna or the Pfizer BioNTech) in study participants vaccinated early vs. those vaccinated later. Estimating the difference in antibody level in patients vaccinated once vs. those vaccinated twice.
The Vaccination for Recovered In-patients with COVID-19 (VATICO) study is a phase 4 open-label trial which will be
- Investigating the difference in antibody level to mRNA (Moderna or the Pfizer BioNTech) in study participants vaccinated early vs. those vaccinated later.
- Estimating the difference in antibody level in patients vaccinated once vs. those vaccinated twice.
Findings from the VATICO study will be useful in determining the usefulness of vaccination in people who have recovered from COVID-19 considering that they would have acquired immunity from the infection. The study will also provide scientific evidence to inform vaccination guidelines for patients who recover from COVID 19 infection.
It will enroll patients under the ACTIV-3/TICO parent study who receive investigational drugs and have achieved sustained recovery from the COVID-19 infection.
The VATICO study will be implemented in collaboration with the University of Abuja Teaching Hospital Gwagwalada (UATH). Dr. Eriobu Nnakelu is the Nigerian Principal Investigator while Drs. Vivian Kwaghe and Habid Zaiyad are co-investigators.
Study duration is from 16 to 24 months and funding for the study is from the National Institute of Allergy and Infectious Diseases (NIAID).